PARP: Poly(ADP-ribose) polymerase catalytic domain
| PAG Title | PARP: Poly(ADP-ribose) polymerase catalytic domain |
| PAG ID | PEX002663 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active 2. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 0 |
| Information Content | Poor |
| Other IDs | PF00644 |
| Base PAG ID | PEX002663 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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